NFco-loading® Technology for Multi-Active
Liposomal Formulations
NFco-loading® is Natural Field's proprietary multi active liposomal delivery technology developed to improve the bioavailability, stability, and absorption of co-encapsulated hydrophilic and lipophilic ingredients. Using ginsenosides instead of cholesterol as membrane stabilizers enables the co-encapsulation of multiple active ingredients with different properties in a single liposomal carrier.
Designed for complex nutraceutical formulations, the technology supports coordinated delivery of multiple actives and helps brands develop differentiated products beyond conventional single-active liposomal formulations.
What Sets the NFco-loading® Nutraceutical Delivery System Apart
Explore the structural and formulation advantages that differentiate NFco-loading® from conventional liposomal delivery systems.
Coordinated Delivery
NFco-loading® encapsulates multiple water- and fat-soluble functional ingredients in a single liposomal system, enabling synchronized release and absorption to ensure synergistic formulation performance.
Membrane Materials
Rare ginsenosides replace cholesterol as functional membrane materials to stabilize the phospholipid bilayer while contributing their own biological activity, making the membrane itself a functional part of the formulation.
and Safer Use
The cholesterol-free membrane design avoids introducing additional cholesterol-related metabolic burden, making the technology suitable for a broader range of consumers and supporting safer long-term use.
Enhanced Absorption
Compared with conventional liposomal systems, NFco-loading® technology introduces ginsenosides as functional membrane components, providing additional opportunities for enhanced ingredient interaction, stability, and absorption performance.
Encapsulated Actives
The multi active liposomal delivery promotes interaction between its bioactive membrane materials and encapsulated actives, potentially supporting synergistic effects and improved overall formulation performance.
Product Development
The stable membrane structure is compatible with capsules, powders, oral liquids, stick packs and other product formats, enabling the development of a diverse range of functional nutrition and wellness products.
NFco-loading® vs. Conventional Liposomes
See how co-loading liposomes differ from conventional liposomes in supporting complex, multi-active nutraceutical formulations.
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Conventional Liposomes |
Comparison |
NFco-loading® Liposomes |
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Phospholipid-based delivery system |
Membrane Design |
Ginsenoside-functionalized membrane innovation |
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Encapsulation and protection of active compounds |
Ingredient Interaction |
Enhanced interaction between delivery system and biological environment |
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Improves stability and transport of encapsulated ingredients |
Intestinal Transport |
Enhances intestinal delivery efficiency through advanced membrane design |
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Improves absorption potential of poorly soluble ingredients |
Absorption Performance |
Maximizes ingredient utilization through improved uptake and transport |
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Single ingredient delivery |
Application Strategy |
Multi-ingredient co-loading solutions for complex formulations |
Co-loading Liposomes
White Paper
Download our White Paper to explore the comprehensive research and learn how to maximize the effectiveness of your active ingredients.
Scientific Evidence of NFco-loading® Technology
To demonstrate the delivery potential of NFco-loading®, selected liposomal formulations were evaluated in a relative bioavailability studies and Caco-2 cell model by comparing their transcellular transport with free actives and conventional liposomal formulations.
Relative Absorption of NFco-loading® Liposomal Curcumin
In Caco-2 cell tests, NFco-loading® Liposomal Curcumin achieved 8.08 times the relative absorption of free curcumin, compared with approximately 3 times for conventional liposomal curcumin.
Relative Bioavailability of NFco-loading® Coenzyme Q10
Under the tested conditions, NFco-loading® Coenzyme Q10 achieved 160% relative bioavailability compared with conventional CoQ10. Developed using proprietary co-loading liposomal technology, it supports dietary supplement formulations requiring improved CoQ10 delivery.
Industry-Recognized Liposomal Co-Loading Platform
NFco-loading® Liposomal Curcumin
Gold Winner - Natural Ingredients
CPHI 2025
NFco-loading® Liposomal Coenzyme Q10
Cardiovascular Health Award
VERY FOOD 2025
NF TriSolve® - Co-Loading Liposomal Solutions for Multiple Health Applications
Explore scientifically validated multi-active formulation solutions developed with NFco-loading® technology for targeted health applications and differentiated nutraceutical products.
NF TriSolve® Anti-Aging Solution
NF TriSolve® MitoAge Complex is a multi-active liposomal anti-aging formula designed for multifaceted benefits, including antioxidant protection, hydration, and skin brightening.
NF TriSolve® Joint Mobility Solution
NF TriSolve® JointFlex Complex is designed for joint comfort, mobility support, and active lifestyle wellness formulations. It combines synergistic actives for cartilage health and movement flexibility.
Co-Loaded Liposomal Formulation Case Study
Natural Field optimized a co-loaded liposomal sleep beverage containing GABA, chamomile extract, and magnesium bisglycinate. By improving raw material selection and flavor balance, we achieved a lighter appearance and cleaner taste. Following successful pilot validation, the customer placed a 120 kg bulk order.
Turn Your Formulation Challenge into a Market-Ready Solution
Natural Field works with you to transform product concepts and formulation needs into practical nutraceutical solutions with a clear path to commercialization.
Identify The Challenge
Have an Ingredient Delivery Challenge?
Need to combine multiple actives, improve ingredient solubility, or maintain formulation stability? Tell us what is holding your product back, and we will evaluate the delivery requirements.
NF co-loading® is designed for more complex liposomal delivery requirements.
• Solubility Support
• Stability Support
• Multi-Active Co-Loading
• Formulation Compatibility
Explore the Solution
From Ingredients to Delivery Solutions
Whether you need a liposomal ingredient, a customized delivery system, or multi-active co-loading, our technical team works with you to develop the right approach for your formulation.
Even if you are starting with a product concept rather than a finalized formula, Natural Field can support your project through:
• Single-Active Liposomal Development
• Multi-Active Co-Loading
• Application-Oriented Formulation Solutions
Start Your Project
Ready to Develop Your Liposomal Solution?
Share your ingredient requirements, formulation needs, or product concept. Our technical team will assess your project and recommend the next development step.
Project Inquiry → Technical Assessment → Solution Development → Scale-Up & Commercial Supply
Discuss Your Formulation Project
Certified for Global Compliance
Our products are certified to international standards, including ISO 9001, HACCP, Halal, and Kosher, supporting compliance and global market access.
Frequently Asked Questions
Q1: What information is needed to start a formulation project?
Q2: Can you develop custom co-loaded formulations?
A: Yes. We offer full OEM support and contract manufacturing for co-loaded liposomal ingredients and finished formulations, including R&D development, stability testing, scale-up production, specification control, and documentation support for international markets.
Q3: How do you ensure the quality and stability of your formulas?
A: Each batch is tested for particle size distribution, encapsulation efficiency, stability under storage conditions, and microbiological limits. Together, these controls help ensure consistent quality, stable structure, and reliable performance across production.
Q4: What is the typical MOQ for co-loaded liposomal ingredients?
A: MOQ depends on formulation complexity and development stage. For some products, trial or custom orders start from 1 kg, while regular bulk orders usually start from 25 kg.
Q5: Can samples be provided before the bulk order?
A: Yes. Samples can be provided for testing and formulation evaluation before commercial production.
Q6 :Do you support international shipping and documentation?
A: We support payment methods like T/T and L/C, etc., and provide standard export packaging and required documentation for international delivery.
Ready to Develop Your Co-Loading Liposomal Ingredient Project?
Connect with Natural Field's technical team to discuss your formulation needs, request samples, or get the right technical documentation.
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